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Li-Fraumeni syndrome
3 OMIM references -
2 associated genes
16 signs/symptoms
PROTEIN INTERACTIONS: 1
Bladder exstrophy
1 OMIM reference -
1 associated gene
14 signs/symptoms
Li-Fraumeni syndrome
Bladder exstrophy

CHEK2
(UniProt - OMIM)
 TP63
(UniProt - OMIM)
TP53
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
TP53
(0.91)
TP63


Citations in the biomedical literature:


Li-Fraumeni syndrome
CHEK2 TP53
Bladder exstrophy
TP63



Li-Fraumeni syndrome
Bladder exstrophy

Synonym(s):
(no synonyms)

Synonym(s):
- Classic exstrophy of the bladder
Classification (Orphanet):
- Rare endocrine disease
- Rare genetic disease
- Rare neurologic disease
- Rare oncologic disease
Classification (Orphanet):
- Rare abdominal surgical disease
- Rare developmental defect during embryogenesis
- Rare genetic disease
- Rare renal disease
- Rare urogenital disease
Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: -
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: neonatal/infancy
Average age of death: normal
Type of inheritance: multigenic/multifactorial
External references:
3 OMIM references -
1 MeSH reference: D016864
External references:
1 OMIM reference -
1 MeSH reference: D001746
Li-Fraumeni syndrome
Bladder exstrophy

Very frequent
- Acute leukemia
- Autosomal dominant inheritance
- Bone / osseous neoplasm / tumor / carcinoma / cancer
- Breast neoplasm / tumor / carcinoma / cancer
- Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer
- Colon neoplasm / tumor / carcinoma / cancer
- Cortical adrenal neoplasm / tumor / carcinoma / cancer
- Lymphoma
- Neoplasms / tumors
- Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer
- Sarcoma
- Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma)
- Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma

Occasional
- Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer
- Melanoma
- Oropharyngeal neoplasm / tumor / carcinoma / cancer


Very frequent
- Anus / rectum anomalies
- Bladder / cloacal exstrophy
- Clitoris / labia majora / labia minora / female external genitalia hypoplasia
- Hypospadias / epispadias / bent penis
- Micropenis / small penis / agenesis
- Umbilical hernia
- Vesicorenal / vesicoureteral reflux

Frequent
- Inguinal / inguinoscrotal / crural hernia
- Recurrent urinary infections
- Urethral anomalies / stenosis / posterior urethral valves / megalocystis

Occasional
- Encopresis / fecal incontinence
- Intestinal / gut / bowel malrotation
- Omphalocele / exomphalos
- Short bowel